Gledhill B, Fraser H M, Donovan B T
J Reprod Fertil. 1982 Jan;64(1):19-23. doi: 10.1530/jrf.0.0640019.
Administration of ovine antiserum containing antibodies against synthetic LH-RH to spayed female ferrets caused an immediate fall in plasma LH concentration and by 2 h after injection circulating levels had declined by 70--80%. A further decline of 50% was observed on Day 2, but by Day 4 a return to normal levels had begun and control values were regained on Day 6. In contrast, the fall in plasma FSH concentration was delayed, with a significant reduction being first observed on Day 2 and minimal values occurring on Day 4. Control values were regained by Day 7. The results accord with the concept that a single hypothalamic releasing factor controls the tonic secretion of both pituitary hormones. However, the slow change in FSH secretion implies that the mechanism for FSH release may be more autonomous than that for LH.
给切除卵巢的雌性雪貂注射含抗合成促黄体激素释放激素抗体的羊抗血清后，血浆促黄体激素（LH）浓度立即下降，注射后2小时，循环水平下降了70% - 80%。在第2天观察到进一步下降50%，但到第4天开始恢复到正常水平，并在第6天恢复到对照值。相比之下，血浆促卵泡激素（FSH）浓度的下降延迟，第2天才首次观察到显著降低，第4天出现最低值。到第7天恢复到对照值。这些结果符合单一下丘脑释放因子控制两种垂体激素的紧张性分泌这一概念。然而，FSH分泌的缓慢变化表明，FSH释放机制可能比LH的释放机制更具自主性。
