Zahradnik H P, Stengele E, Kraut E, Breckwoldt M
Dtsch Med Wochenschr. 1978 Aug 18;103(33):1298-30. doi: 10.1055/s-0028-1129251.
Menstrual blood of 5 dysmenorrhoeic women was collected in tampons during two menstrual cycles without and four cycles with intrauterine progesterone treatment (Progestasert). Three eumenorrhoeic women served as controls. Progesterone was assayed radioimmunologically after purification and extraction. Total progesterone excretion in the menstrual blood was the same in eumenorrhoeic and dysmenorrhoeic women without treatment. An increase of menstrual progesterone excretion by the factor 13 was found during the first bleeding after insertion of progesterone T. After 12 months of treatment with Progestasert only 41.7% (2 alpha less than or equal to 0.001) of the initial progesterone amount per menstruation was found. The progesterone concentration per ml menstrual blood had decreased in the same way but was still clearly higher than eumenorrhoeic values. The results indicate that progesterone controls intrauterine prostaglandin F2alpha formation indirectly.
在两个未进行宫内孕酮治疗（使用Progestasert）的月经周期以及四个进行宫内孕酮治疗的月经周期中，用棉塞收集了5名痛经女性的月经血。三名月经正常的女性作为对照。经纯化和提取后，采用放射免疫法测定孕酮。未经治疗的月经正常和痛经女性月经血中的总孕酮排泄量相同。在插入孕酮T后的第一次出血期间，发现月经孕酮排泄量增加了13倍。在用Progestasert治疗12个月后，每次月经的初始孕酮量仅为41.7%（P＜0.001）。每毫升月经血中的孕酮浓度也以相同方式下降，但仍明显高于月经正常者的值。结果表明，孕酮间接控制子宫内前列腺素F2α的形成。
