针对人凝血因子 VIII 分子的单克隆抗体可中和抗血友病因子和瑞斯托霉素辅因子活性。
Monoclonal antibodies against human factor VIII molecular neutralize antihemophilic factor and ristocetin cofactor activities.
作者信息
Sola B, Avner P, Sultan Y, Jeanneau C, Maisonneuve P
出版信息
Proc Natl Acad Sci U S A. 1982 Jan;79(1):183-7. doi: 10.1073/pnas.79.1.183.
Abstract
A series of monoclonal antibodies have been raised against a preparation of the factor VIII/von Willebrand factor molecule. Of the seven hybridomas showing specific activity against the factor VIII molecule in a solid-phase radioimmunoassay, three (F4.55, F4.77, and F4.264) have been shown to partially inhibit ristocetin-induced platelet aggregation and two (F4.115 and F4.415) inhibit the antihemophilic activity of the factor VIII molecule. An additional monoclonal antibody was directed against a contaminant of the factor VIII preparation and is an antifibrinogen antibody.
摘要
已经制备了一系列针对因子VIII/血管性血友病因子分子制剂的单克隆抗体。在固相放射免疫测定中，对因子VIII分子具有特异性活性的七个杂交瘤中，有三个（F4.55、F4.77和F4.264）已被证明可部分抑制瑞斯托霉素诱导的血小板聚集，还有两个（F4.115和F4.415）可抑制因子VIII分子的抗血友病活性。另外一种单克隆抗体针对的是因子VIII制剂的一种污染物，是一种抗纤维蛋白原抗体。
相似文献
1
Monoclonal antibodies against human factor VIII molecular neutralize antihemophilic factor and ristocetin cofactor activities.针对人凝血因子 VIII 分子的单克隆抗体可中和抗血友病因子和瑞斯托霉素辅因子活性。
Proc Natl Acad Sci U S A. 1982 Jan;79(1):183-7. doi: 10.1073/pnas.79.1.183.
2
[Monoclonal antibodies against the factor VIII/Willebrand factor molecule: inhibition of the cofactor action of ristocetin and the antihemophilic factor].[抗凝血因子 VIII/血管性血友病因子分子的单克隆抗体：瑞斯托菌素和抗血友病因子辅助因子作用的抑制]
C R Seances Acad Sci III. 1981 May 18;292(18):1055-7.
4
5
Enhancement of factor VIII-von Willebrand factor ristocetin cofactor activity by monoclonal antibodies.单克隆抗体对因子VIII-血管性血友病因子瑞斯托霉素辅因子活性的增强作用。
Thromb Haemost. 1985 Aug 30;54(2):510-4.
6
Two novel anti-von Willebrand factor monoclonal antibodies.两种新型抗血管性血友病因子单克隆抗体。
Thromb Res. 2000 Jan 15;97(2):3-13. doi: 10.1016/s0049-3848(99)00122-x.
7
[Studies on the effects of five monoclonal antibodies, polyclonal rabbit antibody and homologous antibody to human F VIII/vWF on ristocetin-induced platelet agglutination and platelet retention by glass bead column].[关于五种单克隆抗体、兔多克隆抗体及人F VIII/vWF同源抗体对瑞斯托菌素诱导的血小板凝集及玻璃珠柱血小板滞留作用的研究]
Rinsho Ketsueki. 1985 Jul;26(7):1042-9.
8
Monoclonal antibody to human platelet glycoprotein I. II. Effects on human platelet function.抗人血小板糖蛋白的单克隆抗体。二。对人血小板功能的影响。
Br J Haematol. 1981 Dec;49(4):511-9. doi: 10.1111/j.1365-2141.1981.tb07259.x.
9
10
Plasma collagen cofactor correlates with von Willebrand factor antigen and ristocetin cofactor but not with bleeding time.血浆胶原蛋白辅助因子与血管性血友病因子抗原及瑞斯托霉素辅因子相关，但与出血时间无关。
Thromb Haemost. 1988 Jun 16;59(3):485-90.
引用本文的文献
1
Genetic mapping using microcell-mediated chromosome transfer suggests a locus for Nijmegen breakage syndrome at chromosome 8q21-24.利用微细胞介导的染色体转移进行基因定位表明，尼曼-匹克氏病断裂综合征的一个基因座位于8号染色体q21 - 24区域。
Am J Hum Genet. 1997 Jun;60(6):1487-94. doi: 10.1086/515461.
2
Human factor VIII procoagulant protein. Monoclonal antibodies define precursor-product relationships and functional epitopes.
J Clin Invest. 1985 Jul;76(1):117-24. doi: 10.1172/JCI111933.
本文引用的文献
1
THE PREPARATION AND SOME PROPERTIES OF FIBRINOGEN PRECIPITATED FROM HUMAN PLASMA BY GLYCINE.用甘氨酸从人血浆中沉淀出的纤维蛋白原的制备及其某些性质
Proc Soc Exp Biol Med. 1963 Aug-Sep;113:989-94. doi: 10.3181/00379727-113-28553.
2
3
Characterization of HLA-D-region antigens by two-dimensional gel electrophoresis. Molecular-genotyping.通过二维凝胶电泳对HLA-D区抗原进行表征。分子基因分型。
J Exp Med. 1980 Aug 1;152(2 Pt 2):18s-36s.
4
Immunologic differentiation of classic hemophilia (factor 8 deficiency) and von Willebrand's dissase, with observations on combined deficiencies of antihemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against antihemophilic factor.经典血友病（因子Ⅷ缺乏症）和血管性血友病的免疫学分型，以及关于抗血友病因子和加速素（因子Ⅴ）联合缺乏症和一种获得性抗血友病因子循环抗凝剂的观察
J Clin Invest. 1971 Jan;50(1):244-54. doi: 10.1172/JCI106480.
5
Ristocetin--a new tool in the investigation of platelet aggregation.瑞斯托菌素——血小板聚集研究中的一种新工具。
Thromb Diath Haemorrh. 1971 Oct 31;26(2):362-9.
6
The mode of action of antibodies which destroy factor VIII. I. Antibodies which have second-order concentration graphs.破坏凝血因子VIII的抗体的作用方式。I. 具有二级浓度曲线的抗体。
Br J Haematol. 1972 Aug;23(2):125-35. doi: 10.1111/j.1365-2141.1972.tb03467.x.
7
Molecular weight estimation and separation of ribonucleic acid by electrophoresis in agarose-acrylamide composite gels.在琼脂糖-丙烯酰胺复合凝胶中通过电泳进行核糖核酸的分子量估计及分离
Biochemistry. 1968 Feb;7(2):668-74. doi: 10.1021/bi00842a023.
8
Quantitative assay of a plasma factor deficient in von Willebrand's disease that is necessary for platelet aggregation. Relationship to factor VIII procoagulant activity and antigen content.对血管性血友病中缺乏的、血小板聚集所必需的一种血浆因子进行定量测定。与凝血因子VIII促凝活性及抗原含量的关系。
J Clin Invest. 1973 Nov;52(11):2708-16. doi: 10.1172/JCI107465.
9
Factor VIII recombination after dissociation by CaCl12.氯化钙解离后因子 VIII 的重组。
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2326-9. doi: 10.1073/pnas.70.8.2326.
10
Factor VIII, a series of homologous oligomers and a complex of two proteins.凝血因子 VIII，一系列同源寡聚体以及两种蛋白质的复合物。
Thromb Res. 1974 Jan;4(1):155-64. doi: 10.1016/0049-3848(74)90211-4.
Zotero 插件