Motta M, Martini L
Proc Soc Exp Biol Med. 1981 Oct;168(1):62-4. doi: 10.3181/00379727-168-41235.
The present studies were designed to assess the effect of neurotensin on the release of LH, FSH, and prolactin in long-term castrated female rats. The animals were implanted in the lateral ventricle of the brain wih a cannula to allow the administration of either neurotensin or the vehicle. The peptide (30 microgram, dissolved in saline) or the control saline solution was injected intraventricularly in a volume of 10 microliter following pentobarbital anesthesia. Blood samples were collected at sacrifice 15, 30 and 60 min after injection. A significant decrease of serum LH levels was already present in neurotensin-treated animals at 15 min, and was maintained up to the end of the experiment. This decrease was not accompanied by any change in FSH or prolactin secretion. The results suggest that this tridecapeptide participates in the control of LH release and provide new data on the separate control of the release of the two gonadotropins.
本研究旨在评估神经降压素对长期去势雌性大鼠促黄体生成素（LH）、促卵泡生成素（FSH）和催乳素释放的影响。将动物的脑侧脑室植入插管，以便给予神经降压素或赋形剂。在戊巴比妥麻醉后，将该肽（30微克，溶解于生理盐水中）或对照生理盐水溶液以10微升的体积脑室内注射。在注射后15、30和60分钟处死动物时采集血样。在神经降压素处理的动物中，15分钟时血清LH水平就已显著降低，并一直维持到实验结束。这种降低并未伴随FSH或催乳素分泌的任何变化。结果表明，这种十三肽参与LH释放的调控，并为两种促性腺激素释放的独立调控提供了新的数据。
