Kucharski L T, Unterwald E M
Schizophr Bull. 1981;7(4):571-3. doi: 10.1093/schbul/7.4.571.
The search for a treatment of tardive dyskinesia (TD) has focused largely on cholinergic and GABAergic agents that are believed to attenuate striatal imbalances and bring about symptomatic control of dyskinetic movements. While numerous reports of the partial effectiveness of acute treatment with cholinergic or GABAergic agents have appeared, the effects of chronic administration of these substance are unclear. Results of chronic administration of cholinergic or GABAergic agents to animals are presented, and it is argued that these substances have the potential of eventually worsening TD. Alternative approaches aimed at modifying the theorized pathophysiology of TD, as opposed to symptom control methods, are presented.
迟发性运动障碍（TD）治疗方法的探索主要集中在胆碱能和GABA能药物上，人们认为这些药物可减轻纹状体失衡并实现对运动障碍症状的控制。虽然已有众多关于胆碱能或GABA能药物急性治疗部分有效性的报告，但这些药物长期给药的效果尚不清楚。本文介绍了对动物长期给予胆碱能或GABA能药物的结果，并指出这些药物最终有可能使TD病情恶化。本文还提出了旨在改变TD理论病理生理学的替代方法，而非症状控制方法。
