Anokhina I P, Kogan B M
Zh Nevropatol Psikhiatr Im S S Korsakova. 1981;81(9):1343-7.
Peculiarities of dopamine metabolism were investigated in 27 patients with various forms of active schizophrenic process. The investigations were carried out by determining the content of dopamine and its metabolites in the blood and urine. In all the patients a considerable rise of the dopamine blood level (284.7 of normal) was revealed: prevalent were bound forms of this amine. The free dopamine content in the blood rose still higher in cases of psychomotor excitation. The dopamine content in the patients' urine was lowered. The determinations of dopamine metabolites, such as, dihydroxyphenylacetic acid, and homovanillic acid showed an insufficiency of dopamine deamination: this was an evidence of a deficient activity of monoamine oxidase. Administration of L-DOPA to schizophrenic patients did not cause a rise of the dopamine blood level (in distinction from normal). The author suggests that the discovered disturbances of dopamine metabolism play a certain role in the pathogenesis of schizophrenia.
对27例患有各种形式的活动性精神分裂症病程的患者的多巴胺代谢特性进行了研究。通过测定血液和尿液中多巴胺及其代谢产物的含量来开展这些研究。在所有患者中均发现多巴胺血液水平显著升高（为正常水平的284.7倍）：该胺的结合形式占主导。在精神运动性兴奋的病例中，血液中游离多巴胺的含量升得更高。患者尿液中的多巴胺含量降低。对多巴胺代谢产物如二羟基苯乙酸和高香草酸的测定表明多巴胺脱氨基不足：这是单胺氧化酶活性不足的证据。给精神分裂症患者服用左旋多巴不会导致多巴胺血液水平升高（与正常人不同）。作者认为所发现的多巴胺代谢紊乱在精神分裂症的发病机制中起一定作用。
