Mileikovskii Iu A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1976;76(5):710-4.
In order to study the correlations between the metabolism of biogenic monoamines and the type of development) of schizophrenia, the morning urine excretion of 30 patients (15 with continuous progressive schizophrenia and 15 with shift-like forms of development) was examined. The author studied the percentage of distribution of data, dophamine, noradrenaline and adrenaline and the correlation between these ingredients in the catecholamine system, as well as the distribution of tryptophane. It was established that in schizophrenia there is a noradrenaline deficit and a drop in the activity of tryptophane metabolism towards the serotonin way. Besides, in patients with continuous progressive forms of the disease there was a simultaneous drop in the intensity of dophamine synthesis from dopha, while in patients with shift-like schizophrenia-an excess of dophamine, conditioned probably not only by an inhibition of phamine-B-oxydase, but by an increase of dophadecarboxylase activity.
为了研究生物源性单胺代谢与精神分裂症的发展类型之间的相关性，对30例患者（15例持续性进行性精神分裂症患者和15例发作样发展形式患者）的晨尿排泄情况进行了检查。作者研究了多巴胺、去甲肾上腺素和肾上腺素的数据分布百分比以及儿茶酚胺系统中这些成分之间的相关性，以及色氨酸的分布情况。结果发现，在精神分裂症患者中存在去甲肾上腺素缺乏，且色氨酸代谢向血清素途径的活性下降。此外，在疾病持续进行性形式的患者中，多巴胺从多巴合成的强度同时下降，而在发作样精神分裂症患者中，多巴胺过量，这可能不仅是由于多巴胺-β-氧化酶的抑制，还由于多巴脱羧酶活性的增加。
