Young D R, Schneider V S
Calcif Tissue Int. 1981;33(6):631-9. doi: 10.1007/BF02409501.
Radiological techniques were utilized for monitoring progressive changes in compact bone in the tibia of monkeys during experimentally induced osteopenia. Bone mass loss in the tibia during restraint was evaluated from radiographs, from bone mineral analysis, and from images reconstructed from gamma ray computerized tomography. The losses during 6 months of restraint tended to occur predominantly in the proximal tibia and were characterized by subperiosteal bone loss, intracortical striations, and scalloped endosteal surfaces. Bone mineral content in the cross section of the tibia declined 17-21%. Tomography demonstrated endosteal widening and reduced mineral content per unit of thickness of cortical bone. In 6 months of recovery, the mineral content of the proximal tibia remained depressed. Effects of the dynamic environment on local-regional changes in various skeletal areas are discussed.
在实验性诱导骨质减少期间，利用放射学技术监测猴子胫骨密质骨的渐进性变化。通过X线片、骨矿物质分析以及伽马射线计算机断层扫描重建的图像来评估束缚期间胫骨的骨量丢失情况。在6个月的束缚期内，骨量丢失主要发生在胫骨近端，其特征为骨膜下骨质流失、皮质内条纹以及骨内膜表面呈扇形。胫骨横截面积的骨矿物质含量下降了17% - 21%。断层扫描显示骨内膜增宽，皮质骨单位厚度的矿物质含量降低。在6个月的恢复期，胫骨近端的矿物质含量仍然较低。文中讨论了动态环境对各个骨骼区域局部变化的影响。
