高磷饮食喂养的大鼠中1,25-二羟维生素D3合成增加。
Increased 1,25-dihydroxyvitamin D3 synthesis in rats fed a high-phosphorus diet.
作者信息
Siu G M, Draper H H
出版信息
Calcif Tissue Int. 1981;33(6):667-72. doi: 10.1007/BF02409506.
Rats fed vitamin D-deficient diets containing 0.6% Ca and 0.3%, 0.6%, 1.2%, or 1.8% P exhibited progressive increments of hypocalcemia and hyperphosphatemia. In vitro assay of 25-hydroxyvitamin D3-1-alpha-hydroxylase (1-alpha-hydroxylase) activity in isolated kidney cortical mitochondria showed that hyperphosphatemia in the presence of hypocalcemia was associated with an increase in enzyme activity. The results indicate that the stimulation of 1-alpha-hydroxylase associated with depressed plasma Ca in rats fed a high-P diet overrides any inhibition of the enzyme that may be caused by excess plasma phosphate.
喂食含0.6%钙和0.3%、0.6%、1.2%或1.8%磷的维生素D缺乏饮食的大鼠出现了低钙血症和高磷血症的逐渐加重。对分离的肾皮质线粒体中25-羟维生素D3-1-α-羟化酶（1-α-羟化酶）活性的体外测定表明，低钙血症情况下的高磷血症与酶活性增加有关。结果表明，喂食高磷饮食的大鼠中，与血浆钙降低相关的1-α-羟化酶的刺激作用超过了血浆磷酸盐过量可能对该酶造成的任何抑制作用。
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