D'Incalci M, Farina P, Sessa C, Mangioni C, Garattini S
Cancer Treat Rep. 1982 Feb;66(2):231-5.
The distribution of hexamethylmelamine (HMM) was investigated in surgical biopsies from 12 patients with pelvic cancer who were given an oral dose of 200 mg at 2-24 hours before the operation. The highest concentrations of HMM were found in tissues, such as omentum and subcutaneous tissue, that have a predominant lipidic component. HMM concentrations in the primary tumor were lower than in other tissues and were similar to those in plasma. HMM concentrations in metastases appeared to be higher than in the primary tumor, and in metastases with a diameter less than 3 mm, drug levels were two to ten times those in larger ones. Plotting the HMM concentrations versus time, utilizing the data from different patients, the elimination half-lives were found to be 9.05, 8.82, and 8.53 in plasma, tumor, and subcutaneous tissue, respectively.
对12例盆腔癌患者进行了六甲基三聚氰胺（HMM）分布情况的研究，这些患者在手术前2至24小时口服了200毫克该药物。在诸如大网膜和皮下组织等具有主要脂质成分的组织中发现了最高浓度的HMM。原发性肿瘤中的HMM浓度低于其他组织，且与血浆中的浓度相似。转移灶中的HMM浓度似乎高于原发性肿瘤，在直径小于3毫米的转移灶中，药物水平是较大转移灶的两到十倍。利用来自不同患者的数据绘制HMM浓度与时间的关系图，发现血浆、肿瘤和皮下组织中的消除半衰期分别为9.05、8.82和8.53。
