D'Incalci M, Bolis G, Mangioni C, Morasca L, Garattini S
Cancer Treat Rep. 1978 Dec;62(12):2117-9.
Plasma levels of hexamethylmelamine were measured by a sensitive and specific gas chromatographic assay in 11 patients after they received oral doses ranging from 120 to 300 mg/m2. Peak levels were reached in 0.5--3 hours and ranged from 0.2 to 20.8 micrograms/ml. The area under the curve ranged from 70.2 to 3606.6 micrograms/ml x minute. The half-life of the beta-phase of elimination also showed considerable variability, ranging between 4.66 and 10.2 hours. These parameters were not related to the dose administered. No plasma accumulation of the drug was observed after daily treatment with hexamethylmelamine for 14--21 days.
采用灵敏且特异的气相色谱分析法测定了11例患者口服剂量为120至300mg/m²后血浆中六甲蜜胺的水平。在0.5至3小时达到峰值水平，范围为0.2至20.8微克/毫升。曲线下面积范围为70.2至3606.6微克/毫升×分钟。消除β相的半衰期也显示出相当大的变异性，在4.66至10.2小时之间。这些参数与给药剂量无关。在六甲蜜胺每日治疗14至21天后，未观察到药物在血浆中的蓄积。
