辅助性细胞诱导中人类T细胞与单核细胞相互作用的遗传学
Genetics of human T cell-monocyte interaction in helper cell induction.
作者信息
Rees A, Feldmann M, Woody J N, Erb P
出版信息
Clin Exp Immunol. 1981 Jun;44(3):445-52.
Abstract
The generation of human antigen-specific helper cells from unprimed peripheral blood lymphoid cells in tissue culture requires the presence of the appropriate number of blood monocytes. The role of the HLA complex in this cell interaction was investigated, by using HLA-type donors, and it was found that the monocytes had to share at least one HLA-DR specificity with the T cell donor. These experiments suggested that the genes controlling the macrophage-T cell interaction are closely associated or in linkage disequilibrium with the HLA-DR region.
摘要
在组织培养中从未致敏的外周血淋巴细胞生成人类抗原特异性辅助细胞需要存在适当数量的血液单核细胞。通过使用HLA类型的供体研究了HLA复合体在这种细胞相互作用中的作用，发现单核细胞必须与T细胞供体至少共享一种HLA-DR特异性。这些实验表明，控制巨噬细胞与T细胞相互作用的基因与HLA-DR区域紧密相关或处于连锁不平衡状态。
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