[氢化可的松对心肌酸性水解酶活性的影响]
[Effect of hydrocortisone on the acid hydrolase activity of the myocardium].
作者信息
Kan A M, Matiushin A I
出版信息
Farmakol Toksikol. 1982 Jan-Feb;45(1):21-4.
A study was made of the effect of hydrocortisone in doses of 10, 25 and 50 mg/kg on the activity of beta-glucosidase, beta-galactosidase and acid phosphatase in the rat heart 1, 3, 6, 12 and 24 hours after single administration of the drug. It was found that the hormone exhibited a stabilizing effect within the first hours of the experiments. Later on labilization of the lysosomal membranes of the myocardium could be observed. The increasing hydrocortisone concentrations induced dose-dependent changes in the activity of the test enzymes.
研究了单次给予剂量为10、25和50mg/kg的氢化可的松后1、3、6、12和24小时对大鼠心脏中β-葡萄糖苷酶、β-半乳糖苷酶和酸性磷酸酶活性的影响。发现该激素在实验的最初几个小时内表现出稳定作用。随后可观察到心肌溶酶体膜的不稳定。氢化可的松浓度的增加导致受试酶活性出现剂量依赖性变化。
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