Schrier D J, Sternick J L, Allen E M, Moore V L
J Immunol. 1982 Mar;128(3):1466-9.
The genetics of BCG-induced anergy was studied in mice by evaluating delayed hypersensitivity to sheep erythrocytes. Data obtained using congenic mice and by linkage analysis suggested that genes linked to the H-2 complex do not influence the development of anergy. However, studies in allotype-congenic partners (BALB/c; BALB.Igb) indicated that anergy was influenced by genes linked to the immunoglobulin heavy chain complex (Igh). Breeding studies indicated that the gene influencing anergy is recessive. These studies were extended by using BXD recombinant inbred mice, and verified that anergy is controlled by genes linked to the Igh complex. Because several markers and a tentative map has been constructed for the Igh complex on chromosome 12 in BXD mice, we suggest that the gene that controls BCG-induced anergy is located on the centrometric side of Igh-C approximately 18 to 28 recombination units.
通过评估对绵羊红细胞的迟发型超敏反应，在小鼠中研究了卡介苗诱导无反应性的遗传学。使用同源基因小鼠并通过连锁分析获得的数据表明，与H-2复合体连锁的基因不影响无反应性的发展。然而，对同种异型同源基因伴侣（BALB/c；BALB.Igb）的研究表明，无反应性受与免疫球蛋白重链复合体（Igh）连锁的基因影响。育种研究表明，影响无反应性的基因是隐性的。这些研究通过使用BXD重组近交系小鼠得到扩展，并证实无反应性由与Igh复合体连锁的基因控制。由于已经为BXD小鼠12号染色体上的Igh复合体构建了几个标记和一个初步图谱，我们认为控制卡介苗诱导无反应性的基因位于Igh-C着丝粒侧约18至28个重组单位处。
