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Effects of encainide and metabolites (MJ14030 and MJ9444) on canine cardiac Purkinje and ventricular fibers.

作者信息

Elharrar V, Zipes D P

出版信息

J Pharmacol Exp Ther. 1982 Feb;220(2):440-7.

PMID:6799644
Abstract
摘要

相似文献

1
Effects of encainide and metabolites (MJ14030 and MJ9444) on canine cardiac Purkinje and ventricular fibers.恩卡胺及其代谢产物（MJ14030和MJ9444）对犬心脏浦肯野纤维和心室纤维的影响。
J Pharmacol Exp Ther. 1982 Feb;220(2):440-7.
2
Effects of encainide on the determinants of cardiac excitability in sheep Purkinje fibers.恩卡胺对绵羊浦肯野纤维心脏兴奋性决定因素的影响。
J Pharmacol Exp Ther. 1985 Jan;232(1):40-8.
3
Electrophysiological effects of encainide and its metabolites in normal canine Purkinje fibers and Purkinje fibers surviving infarction.
Can J Physiol Pharmacol. 1989 Jul;67(7):751-6. doi: 10.1139/y89-120.
4
Effect of encainide and its two major metabolites on cardiac conduction.
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5
Electrophysiological effects of encainide (MJ9067) on canine subendocardial Purkinje fibers surviving infarction.
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6
Electrophysiologic effects of encainide (MJ 9067) on canine Purkinje fibres.
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Electrophysiological effects of encainide on isolated cardiac muscle and Purkinje fibers and on the Langendorff-perfused guinea-pig heart.恩卡胺对离体心肌、浦肯野纤维及Langendorff灌流豚鼠心脏的电生理效应。
Eur J Pharmacol. 1980 Feb 8;61(3):247-62. doi: 10.1016/0014-2999(80)90127-2.
8
Qualitative and quantitative comparison of the cardiac effects of encainide and its three major metabolites in the dog.恩卡胺及其三种主要代谢产物对犬心脏作用的定性和定量比较。
J Pharmacol Exp Ther. 1986 Jun;237(3):907-11.
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Electrophysiological effects of the new antiarrhythmic drug 3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide++ + on dog cardiac muscle.
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Genetically determined stereoselective excretion of encainide in humans and electrophysiologic effects of its enantiomers in canine cardiac Purkinje fibers.人类中恩卡尼的遗传决定的立体选择性排泄及其对映体在犬心脏浦肯野纤维中的电生理效应。
Clin Pharmacol Ther. 1991 May;49(5):488-96. doi: 10.1038/clpt.1991.59.

引用本文的文献

1
Encainide and its metabolites. Comparative effects in man on ventricular arrhythmia and electrocardiographic intervals.恩卡尼及其代谢产物。对人体室性心律失常和心电图间期的比较作用。
J Clin Invest. 1984 Feb;73(2):539-47. doi: 10.1172/JCI111241.
2
New antiarrhythmic drugs.新型抗心律失常药物。
Drugs. 1988 Mar;35(3):286-319. doi: 10.2165/00003495-198835030-00005.
3
Clinical pharmacokinetics of encainide.恩卡尼的临床药代动力学。
Clin Pharmacokinet. 1988 Mar;14(3):141-7. doi: 10.2165/00003088-198814030-00002.
4
Encainide. A review of its pharmacological properties and therapeutic efficacy.
Drugs. 1987 Nov;34(5):519-38. doi: 10.2165/00003495-198734050-00002.
5
Encainide.
Cardiovasc Drugs Ther. 1989 Oct;3(5):691-710. doi: 10.1007/BF01857621.
6
Depression of maximum rate of depolarization of guinea-pig ventricular action potentials by metabolites of encainide.恩卡尼代谢产物对豚鼠心室动作电位最大去极化速率的抑制作用。
Br J Pharmacol. 1989 Jun;97(2):619-25. doi: 10.1111/j.1476-5381.1989.tb11994.x.
7
Pharmacokinetics of encainide in patients with cirrhosis.恩卡尼在肝硬化患者中的药代动力学。
Cardiovasc Drugs Ther. 1991 Aug;5(4):733-9. doi: 10.1007/BF03029748.
8
Antiarrhythmic drug classifications. A critical appraisal of their history, present status, and clinical relevance.抗心律失常药物分类。对其历史、现状及临床相关性的批判性评价。
Drugs. 1991 May;41(5):672-701. doi: 10.2165/00003495-199141050-00002.
9
Stereoselective genetically-determined interaction between chronic flecainide and quinidine in patients with arrhythmias.慢性氟卡尼与奎尼丁在心律失常患者中由基因决定的立体选择性相互作用。
Br J Clin Pharmacol. 1992 Mar;33(3):275-80. doi: 10.1111/j.1365-2125.1992.tb04035.x.