桂利嗪、舒必利和硫乙拉嗪对家兔前庭性眼球震颤影响的比较研究。

A comparative study of the effects of cinnarizine, sulpiride and thiethylperazine on vestibular nystagmus in rabbits.

作者信息

Oosterveld W J

出版信息

Eur J Pharmacol. 1978 Jul 15;50(2):91-6. doi: 10.1016/0014-2999(78)90002-x.

Abstract

The effects of cinnarizine, sulpiride, thiethylperazine and a placebo on vestibular nystagmus in rabbits were investigated. The nystagmus was provoked by means of a torsion swing. A suppressive effect was shown by all drugs and not by the placebo. A fast and strong effect was seen after the administration of sulpiride, however this effect decreased after 1 h. The onset of the effect of cinnarizine was slower but the effect lasted longer. Thiethylperazine had a clear suppressive effect but less strong and shorter than that of the other two drugs.

摘要

研究了桂利嗪、舒必利、硫乙拉嗪和安慰剂对兔前庭性眼球震颤的影响。通过扭转摆动诱发眼球震颤。所有药物均显示出抑制作用，而安慰剂则无此作用。舒必利给药后出现快速且强烈的效果，但1小时后这种效果减弱。桂利嗪的起效较慢，但作用持续时间较长。硫乙拉嗪有明显的抑制作用，但比其他两种药物的作用较弱且持续时间较短。