Goldman A
Recent Results Cancer Res. 1982;80:115-9. doi: 10.1007/978-3-642-81685-7_19.
Twenty-nine patients with pathologically proven Ewing's sarcoma without overt metastases at diagnosis were treated with a protocol designed by The Royal Marsden and St. Bartholomew's Hospital Children's Solid Tumour Group. They received megavoltage radiotherapy to the involved bone and adjuvant chemotherapy with a combination of four cytotoxic drugs. Comparison with a historical control group of 19 patients treated with local surgery or radiotherapy but no initial chemotherapy shows a significant improvement in survival for the study group (P = 0.022). Thirteen patients have failed on the protocol: eight at the original site, four in other bones and only one in the lungs. Sixteen patients remain alive and disease free, 11 of these for over 33 months. The treatment regimen was moderately toxic but there were no treatment-related deaths. These results confirm that an improved survival time and, hopefully, cure rate can be expected by treating Ewing's tumour with high-dose megavoltage radiation and combination chemotherapy. Future goals must be better control of primary lesions and eradication of micrometastases in other bones.
29例经病理证实为尤因肉瘤且诊断时无明显转移的患者，接受了由皇家马斯登医院和圣巴塞洛缪医院儿童实体瘤小组设计的方案治疗。他们接受了对受累骨骼的兆伏级放疗以及四种细胞毒性药物联合的辅助化疗。与19例接受局部手术或放疗但未进行初始化疗的历史对照组相比，研究组的生存率有显著提高（P = 0.022）。13例患者治疗方案失败：8例在原发部位，4例在其他骨骼，仅1例在肺部。16例患者仍存活且无疾病，其中11例已超过33个月。该治疗方案毒性中等，但无治疗相关死亡。这些结果证实，通过高剂量兆伏级放疗和联合化疗治疗尤因肿瘤，有望提高生存时间，并有望提高治愈率。未来的目标必须是更好地控制原发灶并根除其他骨骼中的微转移灶。
