Iatridis P G, Gadarowski J J, Iatridis S G
Acta Haematol. 1981;66(4):257-63. doi: 10.1159/000207131.
In 1969, Ogston et al. reported that the normal activation of fibrinolysis by surface contact requires, in addition to Hageman factor and plasminogen, a HF cofactor which is present in the euglobulin fraction and other factor(s) present in the supernatant. It has also been suggested that the glass-treated plasma is deficient in HF cofactor, In our laboratory the glass-treated plasma was found not to be deficient in HF or in a streptokinase-activated proactivator or in plasminogen. The glass-treated plasma was found deficient in prekallikrein in kininogen and in clotting factors XI, IX, VIII and V. The results presented indicate that HF cofactor activity is not different from that of kallikrein and that HF cofactor does not act as a plasminogen proactivator. Furthermore, the results indicate that the "other factors' present in the supernatant are not involved in contact-activated fibrinolysis.
1969年，奥格斯顿等人报告称，表面接触引发的纤维蛋白溶解正常激活过程，除了需要哈格曼因子和纤溶酶原外，还需要一种存在于优球蛋白组分中的HF辅因子以及上清液中存在的其他因子。也有人提出，经玻璃处理的血浆缺乏HF辅因子。在我们实验室中，发现经玻璃处理的血浆并不缺乏HF、链激酶激活的前激活剂或纤溶酶原。经玻璃处理的血浆被发现缺乏激肽释放酶原、激肽原以及凝血因子XI、IX、VIII和V。所呈现的结果表明，HF辅因子活性与激肽释放酶的活性并无差异，且HF辅因子并不作为纤溶酶原激活剂起作用。此外，结果表明上清液中存在的“其他因子”并不参与接触激活的纤维蛋白溶解过程。
