伴有单克隆IgM（κ）抗-P冷自身溶血素的自身免疫性溶血性贫血

Autoimmune haemolytic anaemia with monoclonal IgM (kappa) anti-P cold autohaemolysins.

作者信息

von dem Borne A E, Mol J J, Joustra-Maas N, Pegels J G, Langenhuijsen M M, Engelfriet C P

出版信息

Br J Haematol. 1982 Feb;50(2):345-50. doi: 10.1111/j.1365-2141.1982.tb01925.x.

DOI:10.1111/j.1365-2141.1982.tb01925.x

Abstract

A patient is described with immunoblastic non-Hodgkin's lymphoma and autoimmune haemolytic anaemia of the cold autoantibody type. The autoantibodies were monoclonal IgM-kappa cold haemagglutinins/haemolysins with blood-group specificity, anti-P. Red-cell autoantibodies directed against blood-group-P antigen have until now only been detected, as polyclonal IgG antibodies, in paroxysmal nocturnal haemoglobinuria.

摘要

本文描述了一名患有免疫母细胞性非霍奇金淋巴瘤及冷自身抗体型自身免疫性溶血性贫血的患者。自身抗体为具有血型特异性的单克隆IgM-κ冷血凝素/溶血素，抗-P。针对血型-P抗原的红细胞自身抗体迄今仅在阵发性夜间血红蛋白尿中作为多克隆IgG抗体被检测到。