Cramer P, Schaison G, Andrieu J M, Boiron M, Bernard J
Bull Cancer. 1981;68(5):456-64.
Between 1965 and 1976, 83 previously untreated children aged 15 years and under, with biopsy-confirmed Hodgkin's disease were assessed, treated, and followed-up at Hoôpital Saint-Louis, Paris. Clinical stages were IA-IIA for 59, IB-IIB for 19, and III-IV for 5 patients. Two main types of treatment were used: - monochemotherapy-radiotherapy in 26 patients who received mantle field irradiation followed by monthly vinblastine injections for 3 years; - 57 patients received a combination of MOPP and radiotherapy. The MOPP-radiotherapy treated patients have a significantly better survival and relapse-free survival than the monochemotherapy-radiotherapy treated patients (86.9 p. cent vs 76.1 p. cent and 83.5 p. cent vs 65.4 p. cent). Thirteen relapses were observed after a median complete remission period of 30 months: 6 patients are now free from disease and one is still under treatment. Ten patients died after a 55 months median survival: 7 died from Hodgkin's Disease and 3 from treatment toxicity. No secondary cancer or leukemia has been observed. The main long-term complications of therapy were sterility in male patients, after chemotherapy, and growth defects and disturbances of thyroid functions after radiotherapy.
1965年至1976年间，巴黎圣路易医院对83名15岁及以下、经活检确诊为霍奇金病且此前未接受过治疗的儿童进行了评估、治疗和随访。临床分期为IA-IIA期的有59例，IB-IIB期的有19例，III-IV期的有5例。采用了两种主要治疗方法：26例患者接受单药化疗-放疗，即接受斗篷野照射，随后每月注射长春花碱，持续3年；57例患者接受MOPP方案与放疗联合治疗。接受MOPP-放疗的患者比接受单药化疗-放疗的患者有显著更好的生存率和无复发生存率（分别为86.9%对76.1%以及83.5%对65.4%）。在中位完全缓解期30个月后观察到13例复发：6例患者目前疾病已缓解，1例仍在接受治疗。10例患者在中位生存期55个月后死亡：7例死于霍奇金病，3例死于治疗毒性。未观察到继发性癌症或白血病。治疗的主要长期并发症是男性患者化疗后出现不育，放疗后出现生长缺陷和甲状腺功能紊乱。
