King M M, McCay P B, Kosanke S D
Cancer Lett. 1981 Dec;14(3):219-26. doi: 10.1016/0304-3835(81)90147-6.
The antioxidant butylated hydroxytoluene (BHT) when fed at a level of 0.3% in a defined semi-purified diet was found to decrease mammary tumor incidence in female Sprague-Dawley rats induced by 7,12-dimethylbenz[a]-anthracene (DMBA). however, no effect of BHT on tumor incidence was seen in animals consuming the same diet, under identical experimental conditions, but treated with the carcinogen nitrosomethylurea (NMU). Differences in effectiveness of BHT as a tumor inhibitor in the 2 model systems, and thoughts as to a possible mechanism of action with regard to BHT are discussed.
在一种特定的半纯化饮食中，以0.3%的水平喂食抗氧化剂丁基羟基甲苯（BHT），发现其可降低7,12-二甲基苯并[a]蒽（DMBA）诱导的雌性斯普拉格-道利大鼠的乳腺肿瘤发病率。然而，在相同实验条件下，食用相同饮食但用致癌物亚硝基甲基脲（NMU）处理的动物中，未观察到BHT对肿瘤发病率有影响。讨论了BHT在这两种模型系统中作为肿瘤抑制剂的有效性差异，以及关于BHT可能的作用机制的思考。
