Bowersox S S, Siegel J M, Sterman M B
Exp Neurol. 1978 Aug;61(1):154-64. doi: 10.1016/0014-4886(78)90187-5.
The toxic derivative of hydrazine, monomethylhydrazine, at a dosage of 10 mg/kg is a potent convulsant, producing tonic-clonic seizures in the cat. In this study the effects of enforced restraint on susceptibility to MMH-induced seizures was examined in naive animals and in cats prepared neurosurgically with indwelling polygraphic recording electrodes. Using a counterbalanced design, latency to seizure following the intraperitoneal administration of the drug (10 mg/kg) was measured twice in all animals, under restraint and in freely moving conditions. Susceptibility to seizures was significantly decreased under the condition of restraint. Additionally, polygraphic recordings showed that restraint was accompanied by an increased incidence of “synchronous” EEG patterns. These results were not explained by metabolic variables, duration of intertrial interval, or changes in weight. The relationship between observed polygraphic patterns and seizure response is discussed in terms of the physiological alterations attendant upon restraint.
肼的毒性衍生物单甲基肼，剂量为10毫克/千克时是一种强效惊厥剂，可使猫发生强直性阵挛性惊厥。在本研究中，对未接触过该药物的动物以及通过神经外科手术植入多导记录电极的猫，研究了强制约束对单甲基肼诱导惊厥易感性的影响。采用平衡设计，在所有动物中，于约束状态和自由活动状态下，对腹腔注射该药物（10毫克/千克）后惊厥发作的潜伏期进行了两次测量。在约束条件下，惊厥易感性显著降低。此外，多导记录显示，约束伴随着“同步”脑电图模式发生率的增加。这些结果无法用代谢变量、试验间隔时间或体重变化来解释。根据约束伴随的生理改变，讨论了观察到的脑电图模式与惊厥反应之间的关系。
