Polatti E, Bolis P F, Ravagni-Probizer M F, Baruffini A, Cavalleri A
Am J Obstet Gynecol. 1978 Aug 1;131(7):792-6. doi: 10.1016/0002-9378(78)90249-1.
The results obtained with intermittent bromocryptine treatment from the fifth day after the beginning of menstruation until the second day after the basal temperature rise, in 14 women with hyperprolactinemic amenorrhea-galactorrhea and in whom menses had previously been induced by continuous treatment, are presented. All women had menses without reappearance of galactorrhea; serum FSH, LH, estradiol, and progesterone followed a normal physiologic trend. Only prolactin rose again in the second phase of the cycle, in which lower levels of progesterone were also found, but without any significant interference in the clinical and hormonal trend. It is stressed that administration of bromocryptine during the first part of the cycle might substitute for continuous administration, thereby reducing drug consumption and hence possible side-effects as well as the cost of treatment.
本文呈现了对14名高催乳素血症性闭经-溢乳妇女进行间歇性溴隐亭治疗的结果。这些妇女月经初潮后第5天开始接受治疗，直至基础体温升高后第2天，此前她们曾通过持续治疗诱导月经来潮。所有妇女均月经来潮且溢乳未再出现；血清促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇和孕酮呈正常生理趋势。仅催乳素在周期的第二阶段再次升高，此阶段孕酮水平也较低，但对临床和激素趋势无显著干扰。需强调的是，在周期的第一部分给予溴隐亭可替代持续给药，从而减少药物消耗，进而降低可能的副作用以及治疗成本。
