Pathological and physical investigations into CO2 laser - tissue interactions with specific emphasis on cervical intraepithelial neoplasm.

Laser tissue interactions were studied to relate the physical biothermal changes observed in treatment of cervical intraepithelial neoplasias. Confirmational changes in epithelium impacted with energies of 25 joules/cm2 were related to experimental and theoretical models. Analysis of cytology, histology, and SEM were compared to a mathematical model and experimental tissue model. The apparent distribution of vaporization and heating in cervical tissue was observed to be an oblate hemispheroid. This geometrical configuration was noted in power densities from 125 W/cm2 to 800 W/cm2. Comparison of the experimental and theoretical models confirmed this geometric heat distribution. Theoretical conclusions concerning destructive modality effectiveness and tissue healing can be deduced from this triple analytical model.