Haspels A A, Luisi M, Kicovic P M
Maturitas. 1981 Dec;3(3-4):321-7. doi: 10.1016/0378-5122(81)90041-4.
The maturation value (MV), cervical mucus parameters (ferning, Spinnbarkeit), oestrone (E1), oestradiol (E2), oestriol (E3), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), thyrotropin (TSH), growth hormone (GH), sex hormone binding globulin (SHBG), corticosteroid binding globulin (CBG) and thyroxin-binding globulin (TBG) were determined in 11 post-menopausal women presenting with vaginal atrophy prior to, and following, treatment with Ovestin vaginal cream containing 0.5 mg/day of E3 for 8 wk. In 6 of the patients E3 was measured during frequent plasma sampling on days 1, 21 and 56; in the same patients and on the same days TRH-stimulated PRL, TSH and GH levels were estimated. While the therapy induced a sharp rise in the MV, there was a moderate effect on ferning/Spinnbarkeit. Baseline E3 rose from undetectable levels to a mean value of 86.8 pmol/l at day 21. E3 levels achieved during frequent plasma sampling were higher on day 1 than on days 21 and 56 - a decline of the areas under the response curves being significant (P2-sided = 0.03). There was a slight suppression of FSH and LH. No changes in the circulating levels of E1, E2, SHBG, CBG, TBG, PRL, TSH and GH were seen. TRH-stimulated PRL, TSH and GH levels remained unaffected. Clinical effect was excellent and no untoward effects were reported.
对11名出现阴道萎缩的绝经后女性在使用含0.5mg/天E3的奥维斯汀阴道乳膏治疗8周之前和之后，测定其成熟值（MV）、宫颈黏液参数（羊齿状结晶、拉丝度）、雌酮（E1）、雌二醇（E2）、雌三醇（E3）、促卵泡生成素（FSH）、促黄体生成素（LH）、催乳素（PRL）、促甲状腺激素（TSH）、生长激素（GH）、性激素结合球蛋白（SHBG）、皮质类固醇结合球蛋白（CBG）和甲状腺素结合球蛋白（TBG）。6名患者在第1、21和56天频繁采集血浆时测定E3；在同一患者的同一天，测定促甲状腺激素释放激素（TRH）刺激后的PRL、TSH和GH水平。治疗使MV急剧上升，对羊齿状结晶/拉丝度有中度影响。基线E3从检测不到的水平升至第21天的平均值86.8pmol/L。频繁采集血浆时第1天的E3水平高于第21天和第56天——反应曲线下面积的下降具有显著性（双侧P = 0.03）。FSH和LH略有抑制。E1、E2、SHBG、CBG、TBG、PRL、TSH和GH的循环水平未见变化。TRH刺激后的PRL、TSH和GH水平未受影响。临床效果极佳，未报告不良反应。
