Wilmer J, Schubert J, Leveling H
Mutat Res. 1981 Dec;90(4):385-97. doi: 10.1016/0165-1218(81)90061-6.
Solutions of 2-deoxy-D-ribose and D-ribose were gamma-irradiated under different experimental conditions and tested for mutagenicity, with and without preincubation, in Salmonella typhimurium. The irradiated sugar solutions were mutagenic in the tester strains TA100 and TA98. Except for malonaldehyde (MDA), which is not mutagenic in the concentrations produced radiolytically, the relative mutagenicities of the individual radiolytic products are unknown. With irradiated solutions of 2-deoxy-D-ribose, a relationship was found between the level of non-MDA aldehydes and the mutagenicity in TA100. Heating the irradiated solutions of 2-deoxy-D-ribose resulted in a temperature-dependent reduction of the mutagenicity. Autoclaved, non-irradiated solutions of 2-deoxy-D-ribose were not mutagenic in the Salmonella test.
在不同实验条件下，对2-脱氧-D-核糖和D-核糖溶液进行γ射线辐照，并在有或无预孵育的情况下，在鼠伤寒沙门氏菌中测试其致突变性。辐照后的糖溶液在测试菌株TA100和TA98中具有致突变性。除了丙二醛（MDA），其在辐射分解产生的浓度下不具有致突变性外，各个辐射分解产物的相对致突变性尚不清楚。对于辐照后的2-脱氧-D-核糖溶液，发现非MDA醛的水平与TA100中的致突变性之间存在关系。加热辐照后的2-脱氧-D-核糖溶液会导致致突变性随温度降低。经高压灭菌的未辐照2-脱氧-D-核糖溶液在沙门氏菌试验中不具有致突变性。
