Jafek B W, Solomons C C, Masson N C, Mahowald M C, Gumprecht T F
Otolaryngol Head Neck Surg. 1981 Nov-Dec;89(6):891-7. doi: 10.1177/019459988108900602.
Malignant hyperthermia (MH) is a chemically induced, genetic myopathy characterized by metabolic and respiratory acidosis, arrhythmias, hyperpyrexia, and muscular rigidity usually occurring during or within 24 hours postanesthesia. It is initiated by some anesthetic drugs, muscle relaxants, and possibly by catecholamines produced by stress. The incidence of the disease is 1:15,000 in populations who have received a general anesthetic. A recently developed platelet bioassay test allows for rapid identification of the susceptible individual, while medication with dantrolene sodium can usually prevent or reverse the syndrome.
恶性高热（MH）是一种化学诱导的遗传性肌病，其特征为代谢性和呼吸性酸中毒、心律失常、高热以及通常在麻醉期间或麻醉后24小时内出现的肌肉强直。它由某些麻醉药物、肌肉松弛剂引发，也可能由应激产生的儿茶酚胺引发。在接受全身麻醉的人群中，该疾病的发病率为1:15000。最近开发的血小板生物测定试验能够快速识别易感个体，而使用丹曲林钠进行药物治疗通常可以预防或逆转该综合征。
