Spätling L, Stähler E, Mohr K, Buchholz R
Prostaglandins. 1982 Jan;23(1):77-83. doi: 10.1016/0090-6980(82)90024-7.
Eight human ovaries were perfused in a closed recirculating system with a semisynthetic, hemoglobin-free medium. Arterial and intraovarian pressures were recorded simultaneously. In three experiments spontaneous pressure changes were noticed. In five experiments pressure changes were induced with human menopausal gonadotropin (hMG) (approximately 70mIU/ml follicle stimulating hormone (FSH) and 40mIU/ml luteotrophic hormone (LH) II. IRP-hMG). Frequency and amplitude of pressure changes in the arterial system and fluctuations in tissue pressure were reduced with indomethacin (20 micrograms/ml). In one experiment 40 micrograms/ml indomethacin had been used. In spite of the high dose of indomethacin arterial and tissue pressure changes were not abolished in all experiments. Therefore it is assumed that vascular and tissue activities are not mediated by prostaglandins only.
在一个封闭的循环系统中，用一种半合成的、不含血红蛋白的培养基对8个人类卵巢进行灌注。同时记录动脉压和卵巢内压。在3个实验中观察到自发的压力变化。在5个实验中，用人绝经期促性腺激素（hMG）（约70mIU/ml卵泡刺激素（FSH）和40mIU/ml促黄体生成素（LH）II. IRP-hMG）诱导压力变化。吲哚美辛（20微克/毫升）可降低动脉系统压力变化的频率和幅度以及组织压力的波动。在一个实验中使用了40微克/毫升的吲哚美辛。尽管吲哚美辛剂量很高，但并非在所有实验中动脉压和组织压变化都被消除。因此推测血管和组织活动并非仅由前列腺素介导。
