大鼠产前给予激素活性化合物后的发育毒性指标。II. 母体体重增加模式。
Indicators of developmental toxicity following prenatal administration of hormonally active compounds in the rat. II. Pattern of maternal weight gain.
作者信息
Rands P L, Newhouse C L, Stewart J L, Bradshaw W S
出版信息
Teratology. 1982 Feb;25(1):45-51. doi: 10.1002/tera.1420250107.
Chronic prenatal exposure of rats to diethylstilbestrol, zeranol, or 3,4,3',4'-tetrachlorobiphenyl produced quantitative and qualitative differences in the cumulative pattern of weight gain during pregnancy. Each of the three compounds, however, exhibited unique characteristics with respect to the effect of increased dose on this response, as well as in the relationship of reduced weight gain to perinatal mortality. The weight deficit after diethylstilbestrol treatment was found to reside in the dam herself, not in any compartment of the gravid uterus. The pattern of maternal weight gain is a useful indicator of developmental toxicity permitting discrimination among structurally diverse chemical agents.
大鼠孕期长期暴露于己烯雌酚、玉米赤霉醇或3,4,3',4'-四氯联苯，会使孕期体重增加的累积模式在数量和质量上产生差异。然而，这三种化合物中的每一种在剂量增加对该反应的影响方面，以及体重增加减少与围产期死亡率的关系方面，都表现出独特的特征。已发现己烯雌酚处理后体重不足存在于母鼠自身，而非妊娠子宫的任何部分。母体体重增加模式是发育毒性的一个有用指标，可用于区分结构各异的化学物质。
Zotero 插件