Aderka D, Djaldetti M, Shoenfeld Y, Shaklai M, Santo M, Berliner S, Weinberger A, Pinkhas J
Acta Haematol. 1982;67(2):119-23. doi: 10.1159/000207037.
A patient with thrombotic thrombocytopenic purpura was treated with 8 U of fresh frozen plasma, resulting in a rapid improvement in her condition and subsequently followed by a prolonged clinical remission. The transmission and scanning electron microscopic examinations of the platelets performed before treatment demonstrated marked anomalies of the platelet morphology, namely, an increased number of abnormally elongated pseudopods with terminal knobs, a decreased number of platelet granules and excess of glycogen and marked anisocytosis. These anomalies remained unchanged when reexamined 2 months after the achievement of the clinical remission. The question whether these platelet abnormalities are an integral part of thrombotic thrombocytopenic purpura and play a role in its pathogenesis, is raised.
一名血栓性血小板减少性紫癜患者接受了8单位新鲜冷冻血浆治疗，病情迅速改善，随后出现长期临床缓解。治疗前对血小板进行的透射和扫描电子显微镜检查显示血小板形态有明显异常，即异常伸长的伪足数量增加且末端有小结，血小板颗粒数量减少，糖原过量，且明显大小不均。在实现临床缓解2个月后复查时，这些异常情况仍未改变。由此提出了这些血小板异常是否是血栓性血小板减少性紫癜的一个组成部分并在其发病机制中起作用的问题。
