Hattori A, Tatewaki W, Fuse I, Shibata A
Sado General Hospital.
Nihon Rinsho. 1993 Jan;51(1):122-8.
The morphology of circulating platelets in thrombotic thrombocytopenic purpura (TTP) was studied, and basic mechanism of the characteristic shape abnormality found in TTP was investigated in in vitro condition. The platelet shape was spineless sphere (spherical platelets without pseudopods), and shape change persisted 2 months after remission. This type of platelets were produced by long term of activation of normal resting platelets by several agonists except ADP, and induced by dysfunction of both microtubules and microfilaments. These suggest that the shape change in TTP is not specific, but a good parameter for the activity of TTP. PAF activity by the method of Kelton et al. (1984) was detected in only 1 out of 30 samples from 10 patients. PSCF activity was found in 9 out of 29 samples from 10 patients independently from disease activity. Both activities does not reflect the activity of TTP.
对血栓性血小板减少性紫癜（TTP）患者循环血小板的形态进行了研究，并在体外条件下探究了TTP中发现的特征性形状异常的基本机制。血小板形状为无棘球（无伪足的球形血小板），且形状改变在缓解后持续2个月。这种类型的血小板是由除ADP外的几种激动剂长期激活正常静息血小板产生的，并由微管和微丝功能障碍诱导产生。这些表明TTP中的形状改变并非特异性的，而是TTP活性的一个良好参数。采用Kelton等人（1984年）的方法检测，10例患者的30份样本中仅有1份检测到血小板活化因子（PAF）活性。在10例患者的29份样本中有9份检测到血小板第三因子（PSCF）活性，且与疾病活动无关。这两种活性均不能反映TTP的活性。
