肝病患者血小板对玻璃珠的黏附性

Platelet adhesiveness to glass beads in liver disease.

作者信息

Langley P G, Hughes R D, Williams R

出版信息

Acta Haematol. 1982;67(2):124-7. doi: 10.1159/000207038.

DOI:10.1159/000207038

Abstract

Patients with liver disease have abnormal platelet function. We have investigated the retention of platelets to glass beads in fulminant hepatic failure, cirrhosis and normal controls. Glass bead retention was significantly increased in fulminant hepatic failure (91.5 +/- 4.8%, n = 10) compared with controls (80.2 +/- 8.5%, n = 10) whereas it was significantly reduced in cirrhosis (46.2 +/- 26.8%, n = 10). The increased platelet adhesiveness might predispose to the formation of platelet aggregates in the blood observed during charcoal haemoperfusion in patients with fulminant hepatic failure.

摘要

肝病患者存在血小板功能异常。我们研究了暴发性肝衰竭、肝硬化患者及正常对照者的血小板对玻璃珠的黏附情况。与对照组（80.2±8.5%，n = 10）相比，暴发性肝衰竭患者（91.5±4.8%，n = 10）的玻璃珠黏附率显著升高，而肝硬化患者（46.2±26.8%，n = 10）的玻璃珠黏附率则显著降低。血小板黏附性增加可能促使暴发性肝衰竭患者在进行活性炭血液灌流时血液中形成血小板聚集体。