Grüngreiff K, Abicht K, Kluge M, Presser H J, Franke D, Kleine F D, Klauck S, Diete U
Clinic of Internal Medicine, Institute for Clinical Chemistry, Medical Academy of Magdeburg, German Democratic Republic.
Z Gastroenterol. 1988 Aug;26(8):409-15.
Zinc is essential to numerous metabolic processes in the organism, multiform symptoms being found especially in deficiencies. In addition to nutritional factors, diseases such as cirrhosis of the liver. Crohn's disease and chronic renal diseases are relevant in this context. In the present work, serum zinc levels were investigated in 109 patients with various chronic liver diseases. The lowest serum zinc concentrations were seen in patients with decompensated hepatic cirrhosis with coma. Patients with decompensated alcoholic cirrhosis had lower zinc levels as subjects with nonalcoholic cirrhosis. None of the groups exhibited a significant change in serum zinc levels during the treatment period. Laboratory data (such as transaminases, thromboplastin time, alkaline phosphatase, total proteins) did not correlate with the serum zinc concentrations. The concentration of plasma ammonia, however, appeared to be inversely related to the serum zinc levels. Thus, patients with coma had maximum ammonia and minimum zinc levels.
锌对机体的众多代谢过程至关重要，尤其是在缺乏锌时会出现多种症状。除营养因素外，诸如肝硬化、克罗恩病和慢性肾病等疾病在这方面也有影响。在本研究中，对109例患有各种慢性肝病的患者的血清锌水平进行了调查。血清锌浓度最低的是失代偿期肝昏迷患者。失代偿期酒精性肝硬化患者的锌水平低于非酒精性肝硬化患者。在治疗期间，所有组的血清锌水平均未出现显著变化。实验室数据（如转氨酶、凝血酶原时间、碱性磷酸酶、总蛋白）与血清锌浓度无关。然而，血浆氨浓度似乎与血清锌水平呈负相关。因此，昏迷患者的氨含量最高，锌含量最低。
