Johnson K A
Aust Vet J. 1981 Oct;57(10):474-8. doi: 10.1111/j.1751-0813.1981.tb05770.x.
Bilateral forelimb deformities associated with retained cartilage cores in the distal ulna were diagnosed in 8 immature giant breed dogs. Five of the dogs were autopsied. Histopathological examination of the distal ulnar growth plate revealed a localised central thickening due to the accumulation of hypertrophic chondrocytes which had failed to undergo the usual development to degeneration. Also the intercellular matrix septa of this cartilage were not calcified. Projections of the abnormal cartilage even persisted into the primary spongiosa. These abnormalities in the process of endochondral ossification of the growth plate produced the lesion of retained cartilage core which was responsible for the development of forelimb deformity.
在8只未成熟的大型犬中诊断出与尺骨远端残留软骨核心相关的双侧前肢畸形。其中5只犬进行了尸检。对尺骨远端生长板进行组织病理学检查发现，由于肥大软骨细胞的积聚导致局部中央增厚，这些肥大软骨细胞未能经历正常的退变过程。而且该软骨的细胞间基质隔未钙化。异常软骨的突出甚至持续延伸至初级松质骨。生长板软骨内成骨过程中的这些异常产生了残留软骨核心病变，这是前肢畸形发展的原因。
