Zaman R, Kendall M J, Biggs P I
Br J Clin Pharmacol. 1982 Apr;13(4):507-12. doi: 10.1111/j.1365-2125.1982.tb01412.x.
1 The effect of acebutolol, a relatively selective beta-adrenoceptor blocking drug and propranolol, a non-selective one, on the hypoglycaemic action of glibenclamide after an oral glucose load has been investigated in a group of maturity-onset diabetic patients. 2 Glibenclamide significantly reduced the blood glucose levels and both acebutolol and propranolol, at therapeutic doses, were found to modify this action significantly. 3 The effect of acebutolol was slightly less than that of propranolol. The difference was not statistically significant. 4 The modes of action of sulphonylureas are reviewed and it is suggested that beta-adrenoceptor blockers may modify their effect on insulin release. This appears to be a drug interaction rather than an effect of beta-adrenoceptor blockade on glucose tolerance.
1 在一组成年型糖尿病患者中，研究了相对选择性β-肾上腺素能受体阻断药醋丁洛尔和非选择性β-肾上腺素能受体阻断药普萘洛尔对口服葡萄糖负荷后格列本脲降血糖作用的影响。2 格列本脲显著降低血糖水平，且发现治疗剂量的醋丁洛尔和普萘洛尔均能显著改变这一作用。3 醋丁洛尔的作用略小于普萘洛尔。差异无统计学意义。4 对磺脲类药物的作用方式进行了综述，并提出β-肾上腺素能受体阻断剂可能会改变它们对胰岛素释放的作用。这似乎是一种药物相互作用，而不是β-肾上腺素能受体阻断对葡萄糖耐量的影响。
