Newman R J
Br Med J. 1977 Sep 3;2(6087):601-3. doi: 10.1136/bmj.2.6087.601.
Metoprolol and acebutolol, two supposedly cardioselective beta-adrenoceptor antagonists, were tested in 11 healthy men against propranolol, a non-selective drug, for their effect on plasma free fatty acid concentrations before and after insulin. The fasting concentrations of free fatty acid were significantly reduced after acebutolol and propranolol, and their return to normal after insulin was delayed. Metoprolol had no significant effect on free fatty acid levels either before or after insulin. Although both selective and non-selective beta-blocking drugs should be expected to delay the return of free fatty acid values to normal after insulin, in contrast to propranolol and acebutolol, metoprolol had no such effect. This suggests that metoprolol may not be as effective as the other two drugs in controlling lipid metabolism during long-term treatment with beta-adrenoceptor antagonists.
美托洛尔和醋丁洛尔这两种被认为具有心脏选择性的β-肾上腺素能受体拮抗剂，在11名健康男性中与非选择性药物普萘洛尔进行了对比测试，观察它们对胰岛素前后血浆游离脂肪酸浓度的影响。醋丁洛尔和普萘洛尔使空腹游离脂肪酸浓度显著降低，且胰岛素作用后其恢复正常的时间延迟。美托洛尔对胰岛素前后的游离脂肪酸水平均无显著影响。尽管选择性和非选择性β受体阻滞剂都应会延迟胰岛素作用后游离脂肪酸值恢复正常的时间，但与普萘洛尔和醋丁洛尔不同，美托洛尔没有这种作用。这表明在长期使用β-肾上腺素能受体拮抗剂治疗期间，美托洛尔在控制脂质代谢方面可能不如其他两种药物有效。
