普萘洛尔、美托洛尔和醋丁洛尔对胰岛素诱导的低血糖的比较。
Comparison of propranolol, metoprolol, and acebutolol on insulin-induced hypoglycaemia.
作者信息
Newman R J
出版信息
Br Med J. 1976 Aug 21;2(6033):447-9. doi: 10.1136/bmj.2.6033.447.
Abstract
Metoprolol and acebutolol, two supposedly cardio-selective beta-adrenergic recptor blocking agents, were tested in healthy volunteers against propranolol, a non-selective drug, for their effect on blood glucose levels during insulin-induced hypoglycaemia. There was not significant difference between propranolol and metoprolol, which both potentiated the initial hypoglycaemic action of the insulin and delayed the return to normoglycaemia. Acebutolol, even though potentiating the initial hypoglycaemia, did not possess a significant delaying effect. A similar trial should be undertaken in diabetics to determine with certainty the safety of such drugs in diabetes mellitus.
摘要
美托洛尔和醋丁洛尔这两种被认为具有心脏选择性的β-肾上腺素能受体阻滞剂，在健康志愿者中与非选择性药物普萘洛尔进行了对比测试，以观察它们在胰岛素诱导的低血糖期间对血糖水平的影响。普萘洛尔和美托洛尔之间没有显著差异，二者均增强了胰岛素最初的降血糖作用，并延迟了血糖恢复正常的时间。醋丁洛尔尽管增强了最初的低血糖作用，但没有显著的延迟效果。应该在糖尿病患者中进行类似试验，以确定此类药物在糖尿病中的安全性。
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Role of beta-adrenergic receptors in counterregulation to insulin-induced hypoglycemia.β-肾上腺素能受体在对抗胰岛素诱导的低血糖中的作用。
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