Sallam H N, Marinho A O, Collins W P, Rodeck C H, Campbell S
Br J Obstet Gynaecol. 1982 Feb;89(2):155-9. doi: 10.1111/j.1471-0528.1982.tb04684.x.
Real-time ultrasound scanning of ovarian follicles was performed during 61 cycles in 22 infertile patients being treated with sequential injections of human menopausal gonadotrophin (hMG) and human chorionic gonadotrophin (hCG). Total 24-h urinary oestrogens were estimated (and in 13 cycles plasma oestradiol) but the amount of gonadotrophin given was based mainly on the ultrasound findings. A retrospective analysis of the results showed that there was a poor statistical correlation between the diameter of the largest follicle and the total urinary oestrogens (r=0.39) and with the level of plasma oestradiol (r=0.56), although similar clinical information was obtained by all methods. Ovulation was induced in 58 cycles when the leading follicle had a mean diameter of 20-25 mm (mean 21.3 mm); follicular rupture was observed in 57 cycles and in these cases there was biochemical evidence of luteinization (plasma progesterone greater than 15 nmol/1; total urinary pregnanediol greater than 8 nmol/24h). Three patients (three cycles) were not given hCG; one developed micropolycystic ovaries and two showed evidence of hyperstimulation (one follicle greater than 25 mm diameter, three or more follicles 20-25 mm diameter). Twelve patients became pregnant, all with single fetuses. Subsequently one aborted, one had an ectopic pregnancy, three gave birth to normal babies at term and seven pregnancies are continuing. Real-time ultrasound scanning of ovarian follicles is a simple, practical method for monitoring follicular growth during the administration of hMG and predicting the response to hCG.
对22名接受人绝经期促性腺激素（hMG）和人绒毛膜促性腺激素（hCG）序贯注射治疗的不孕患者的61个周期进行了卵巢卵泡的实时超声扫描。测定了24小时尿雌激素总量（13个周期还测定了血浆雌二醇），但给予促性腺激素的量主要基于超声检查结果。对结果的回顾性分析表明，尽管所有方法获得的临床信息相似，但最大卵泡直径与尿雌激素总量之间的统计相关性较差（r = 0.39），与血浆雌二醇水平的相关性也较差（r = 0.56）。当主导卵泡平均直径为20 - 25 mm（平均21.3 mm）时，58个周期诱导排卵；在57个周期观察到卵泡破裂，在这些病例中有黄体化的生化证据（血浆孕酮大于15 nmol/L；24小时尿孕二醇总量大于8 nmol）。3名患者（3个周期）未给予hCG；1名出现微多囊卵巢，2名有过度刺激的证据（1个卵泡直径大于25 mm，3个或更多卵泡直径为20 - 25 mm）。12名患者怀孕，均为单胎。随后1例流产，1例宫外孕，3例足月分娩正常婴儿，7例妊娠仍在继续。卵巢卵泡的实时超声扫描是一种简单、实用的方法，可用于监测hMG给药期间卵泡的生长情况并预测对hCG的反应。
