Smith M, Gunther R, Zaiss C, Flynn J, Demling R
Circ Shock. 1981;8(6):647-56.
We compared the response of the pulmonary microcirculation to a 5-hr infusion of soybean lipoxygenase with that seen after endotoxin. We monitored microvascular integrity using lung lymph flow QL and lymph/plasma (L/P) protein ratio in unanesthetized sheep. We noted a twofold to threefold increase in QL and a slight decrease in L/P ratio beginning about 1 hr after onset of the lipoxygenase infusion. Leukocyte count decreased significantly and lymph lysosomal enzyme activity increased. Pulmonary artery pressure initially increased from 16 to 31 mm Hg, then decreased to 25 mm Hg during continued infusion. Platelet count remained constant. Parameters returned to baseline several hours after infusion. This pulmonary vascular pressure and lymph flow response was very similar to that seen in the increased permeability phase of endotoxin. A decrease on the L/P ratio and a constant rather than a decreased platelet count were findings different from those seen after endotoxin.
我们比较了肺微循环对内毒素注入后和大豆脂氧合酶5小时输注后的反应。我们在未麻醉的绵羊身上，通过肺淋巴流量QL和淋巴/血浆（L/P）蛋白比率监测微血管完整性。我们注意到，在脂氧合酶输注开始约1小时后，QL增加了两倍至三倍，L/P比率略有下降。白细胞计数显著降低，淋巴溶酶体酶活性增加。肺动脉压最初从16毫米汞柱升至31毫米汞柱，然后在持续输注期间降至25毫米汞柱。血小板计数保持不变。输注后数小时，各项参数恢复至基线水平。这种肺血管压力和淋巴流量反应与内毒素通透性增加阶段所见的反应非常相似。L/P比率降低以及血小板计数保持不变而非降低是与内毒素注入后不同的发现。
