格雷夫斯病患者血清溶酶体酸性水解酶活性

Serum lysosomal acid hydrolase activities in Graves' disease.

作者信息

Guillou H, David V, Lorcy Y, Le Treut A, Allannic H, Le Gall J Y

出版信息

Clin Chim Acta. 1982 Apr 8;120(2):219-24. doi: 10.1016/0009-8981(82)90158-9.

Abstract

The activities of seven lysosomal enzymes (alpha-D-glucosidase, beta-D-galactosidase, beta-D-glucuronidase, hexosaminidase, alpha-L-fucosidase, alpha-D-mannosidase, acid phosphatases) were studied in the serum of 31 untreated patients with Graves' disease, 30 treated hyperthyroid patients whose clinical abnormalities had disappeared and whose hormones had returned to euthyroid levels, and 34 controls. The hyperthyroid state is characterized by increased serum levels of alpha-D-glucosidase, beta-D-glucuronidase, hexosaminidase and especially of alpha-L-glucosidase and alpha-D-mannosidase. In contrast, neither beta-D-galactosidase nor acid phosphatases serum levels were significantly modified. After antithyroid treatment, the activities of these enzymes returned to normal levels, except for alpha-D-mannosidase. The interpretation of these changes in serum acid hydrolases activities is controversial.

摘要

研究了31例未经治疗的格雷夫斯病患者、30例临床异常消失且激素恢复至甲状腺功能正常水平的经治疗的甲亢患者以及34名对照者血清中七种溶酶体酶（α-D-葡萄糖苷酶、β-D-半乳糖苷酶、β-D-葡萄糖醛酸酶、己糖胺酶、α-L-岩藻糖苷酶、α-D-甘露糖苷酶、酸性磷酸酶）的活性。甲亢状态的特征是血清中α-D-葡萄糖苷酶、β-D-葡萄糖醛酸酶、己糖胺酶，尤其是α-L-葡萄糖苷酶和α-D-甘露糖苷酶水平升高。相比之下，β-D-半乳糖苷酶和酸性磷酸酶的血清水平均未发生显著改变。抗甲状腺治疗后，除α-D-甘露糖苷酶外，这些酶的活性恢复至正常水平。对血清酸性水解酶活性变化的解释存在争议。