Kudriashov B A, Liapina L A
Fiziol Zh SSSR Im I M Sechenova. 1978 Jun;64(6):771-6.
The complexes of heparin with components of tissue thromboplastine occurring in vivo and in vitro, reveal an anticoagulating and antipolymerizational effects as well as a nonfermentative fibrinolytic activity. The latter becomes obvious in presence of proteinase inhibitors. On i. v. administration, the complex increases the fibrinolytic and anticoagulating properties of the blood. Its nonfermentative fibrinolytic activity in the bloodstream lasts for 60--90 min.
肝素与体内和体外组织凝血活酶成分形成的复合物,具有抗凝、抗聚合作用以及非酶促纤溶活性。在存在蛋白酶抑制剂的情况下,后者变得明显。静脉给药时,该复合物可增强血液的纤溶和抗凝特性。其在血流中的非酶促纤溶活性持续60 - 90分钟。