Murri L, Parenti G, Bonuccelli U, Lenzi B, Del Tacca M
Ital J Neurol Sci. 1980 Oct;1(4):225-30.
Phenobarbital (PB) was tested for its efficacy in averting post-traumatic epilepsy (PTE) in patients with non-missile head injuries. The protocol envisaged the administration of PB throughout a period of two years in randomly assigned doses ranging from 0.5 to 1.5 and from 1.6 to 2.5 mg/kg/day. The study included neurologic examination, EEG and plasma PB levels. Ninety patients, 83 of whom with serious head injury followed the prescribed treatment for the entire period. Two adult patients manifested seizures 5 and 10 months after the trauma. They were being treated with doses over 1.5 mg/kg/day. Another patient had a seizure six months after the end of the prophylaxis. Low doses of PB and monitoring permitted a reduction of side effects. The low incidence of PTE indicates that PB has an efficient prophylactic effect. The results also show that a low dosage has a favourable effect.
对苯巴比妥（PB）预防非穿透性头部损伤患者创伤后癫痫（PTE）的疗效进行了测试。该方案设想在两年时间内，按随机分配的剂量服用PB，剂量范围为0.5至1.5毫克/千克/天以及1.6至2.5毫克/千克/天。该研究包括神经学检查、脑电图（EEG）和血浆PB水平检测。90名患者参与研究，其中83名重度头部损伤患者在整个研究期间都遵循了规定的治疗方案。两名成年患者在创伤后5个月和10个月出现癫痫发作，他们当时接受的剂量超过1.5毫克/千克/天。另一名患者在预防期结束6个月后出现癫痫发作。低剂量的PB及监测使得副作用有所减少。PTE的低发病率表明PB具有有效的预防作用。结果还显示低剂量具有良好效果。
