Franceschetti S, Binelli S, Casazza M, Lodrini S, Panzica F, Pluchino F, Solero C L, Avanzini G
Department of Neurophysiology, Istituto Neurologico C. Besta, Milano, Italy.
Acta Neurochir (Wien). 1990;103(1-2):47-51. doi: 10.1007/BF01420191.
One hundred and twenty-eight adult patients presenting with and operated on for supratentorial neoplasms were studied. Sixty-five had preoperative seizures and were treated with antiepileptic drugs (AEDs). Among the 63 patients without preoperative epileptic fits, 41 were given AEDs (either phenobarbital or phenytoin) as prophylactic treatment and 22 were not treated. The preoperative epilepsy course was considered with respect to tumour site and histological type. Early and late postoperative seizure occurrence was considered in the different groups of patients. The results suggest the usefulness of a short term preventive treatment with AEDs after surgery in patients without preoperative seizures. In patients with preoperative epilepsy, AEDs should be continued after surgery. However long-term AEDs treatment should not be recommended in patients without preoperative epilepsy. In fact, no significant difference in late seizure occurrence was found between preventively treated and untreated patients.
对128例幕上肿瘤患者进行了研究，这些患者均接受了手术治疗。65例患者术前有癫痫发作，接受了抗癫痫药物（AEDs）治疗。在63例术前无癫痫发作的患者中，41例接受了AEDs（苯巴比妥或苯妥英）预防性治疗，22例未接受治疗。根据肿瘤部位和组织学类型对术前癫痫病程进行了分析。对不同组患者术后早期和晚期癫痫发作情况进行了观察。结果表明，对于术前无癫痫发作的患者，术后短期使用AEDs进行预防性治疗是有效的。对于术前有癫痫的患者，术后应继续使用AEDs。然而，对于术前无癫痫的患者，不建议长期使用AEDs治疗。事实上，预防性治疗组和未治疗组在晚期癫痫发作发生率上没有显著差异。
