Mogil'nitskaia L V, Shugaleĭ V S
Fiziol Zh SSSR Im I M Sechenova. 1978 Jul;64(7):1035-8.
The autolysis and the neutral proteinase activity with respect to protamine in the brain and liver of rats were studied during cold adaptation, on the 1st, 3rd, 7th, 15th, and 45th days in the cold chamber at 2--4 degrees C. A short cold effect (1--3 days) decreases the brain autolysis by 33%, the liver one by 18%. The activity of protamine-lytic peptide-hydrolase diminishes nearly by half both in the brain and in the liver. In cold-adapted rats (45 days) the autolysis increases by 50% in the brain and by 24% in the liver. The activity of neutral peptide-hydrolase remains lowered by 43% in the brain and by 36% in the liver. Thus, only autolytic processes are intensified in cold-adapted animals while the neutral peptide-hydrolase does not participate in the increasing protein catabolism in the brain and liver.
在2-4摄氏度的冷室中，于冷适应的第1、3、7、15和45天，研究了大鼠脑和肝脏中自溶作用以及对鱼精蛋白的中性蛋白酶活性。短期冷效应（1-3天）使脑自溶作用降低33%，肝脏自溶作用降低18%。脑和肝脏中鱼精蛋白分解肽水解酶的活性几乎降低一半。在冷适应大鼠（45天）中，脑自溶作用增加50%，肝脏自溶作用增加24%。中性肽水解酶的活性在脑中仍降低43%，在肝脏中降低36%。因此，在冷适应动物中只有自溶过程增强，而中性肽水解酶不参与脑和肝脏中蛋白质分解代谢的增加。
