[Effect of cold acclimatization on acid peptide hydrolase activity in lysosome enriched fractions of rat brain and liver tissue].

On the 3rd day of cold acclimation (2 degrees-4 degrees C) membrane destabilization occurs in the rat brain followed by enzyme outflow from lysosomas into citoplasm. On the 15th day the enzyme activity returned to control level, whereas on the 30th and 45th days this activity enhanced in lysosomic fraction and declined in the supraprecipitate fraction. By the moment of adaptation (the 45th day) stabilization of lysosomic membranes occurred. The membrane destabilization also took place in the liver. Stabilization of the lysosomic membranes occurred at the moment of the animals coming out of stress state.