Shapiro G G, Furukawa C T, Pierson W E, Bierman C W
J Allergy Clin Immunol. 1982 Apr;69(4):365-9. doi: 10.1016/0091-6749(82)90147-6.
Methacholine sensitivity was evaluated in 166 young subjects who had normal resting spirometric values but who presented problems suggesting lower airways hyperreactivity. Fifty-eight patients (35%) did not have significant sensitivity. The diagnosis of asthma was excluded in this subgroup. Forty-one patients (25%) had mild methacholine sensitivity, 49 (30%) had moderate sensitivity, and 18 (11%) had extreme methacholine sensitivity. Many patients who reacted had chief complaints of cough, bronchitis, or other low respiratory-tract symptoms and did not complain of wheezing. Methacholine challenge helped to clarify appropriate therapy in these individuals. One-year follow-up of these patients showed most patients to be continuing the therapeutic regimen that had been prescribed initially. Methacholine bronchoprovocation was a useful adjunct to management of this large outpatient population of children and young adults and deserves attention as a procedure relevant to patients care, not solely as an investigational test.
对166名静息肺量计值正常但存在提示下呼吸道高反应性问题的年轻受试者进行了乙酰甲胆碱敏感性评估。58名患者（35%）无显著敏感性。该亚组排除了哮喘诊断。41名患者（25%）有轻度乙酰甲胆碱敏感性，49名（30%）有中度敏感性，18名（11%）有极度乙酰甲胆碱敏感性。许多有反应的患者主要抱怨咳嗽、支气管炎或其他下呼吸道症状，而没有喘息症状。乙酰甲胆碱激发试验有助于明确这些个体的适当治疗方法。对这些患者进行的一年随访显示，大多数患者继续采用最初规定的治疗方案。乙酰甲胆碱支气管激发试验是管理这一大量儿童和年轻成人门诊患者的有用辅助手段，作为一种与患者护理相关的程序值得关注，而不仅仅是作为一项研究性试验。
