Fogelman I, Bessent R
J Nucl Med. 1982 Apr;23(4):296-300.
Twenty-four-hour measurements of whole-body retention (WBR) of Tc-99m diphosphonate (a sensitive measure of skeletal metabolism) have been obtained in 250 healthy volunteer subjects. WBR values were found to fall from the age of 20 yr until 35 yr and then in men to rise linearly thereafter. Women showed a similar pattern initially but there was a marked rise in WBR corresponding to the menopausal years. Our results lend support to the belief that skeletal metabolism increases with age. It is suggested that some imbalance must always exist between resorption and formation in bone, with net loss of bone mineral, and increasing levels of skeletal metabolism will exaggerate this imbalance and accelerate the rate of bone loss.
对250名健康志愿者进行了锝-99m二膦酸盐全身潴留（WBR，骨骼代谢的一项敏感指标）的24小时测量。发现WBR值从20岁到35岁呈下降趋势，之后在男性中呈线性上升。女性最初呈现类似模式，但在绝经期间WBR有显著上升。我们的结果支持了骨骼代谢随年龄增长而增加的观点。有人提出，骨吸收与骨形成之间必定始终存在某种失衡，伴有骨矿物质净丢失，而骨骼代谢水平的升高会加剧这种失衡并加速骨质流失速度。
