正电子发射断层扫描-磁共振成像（PET-MRI）在代谢性骨病研究中的应用。
PET-MRI for the Study of Metabolic Bone Disease.
机构信息
Department of Radiology, Stanford University, 1201 Welch Rd, Stanford, CA, 94305, USA.
Bioengineering, Stanford University, Stanford, CA, USA.
出版信息
Curr Osteoporos Rep. 2018 Dec;16(6):665-673. doi: 10.1007/s11914-018-0482-4.
PURPOSE OF REVIEW
This review article attempts to summarize the current state and applications of the hybrid imaging modality of PET-MRI to metabolic bone diseases. The advances of PET and MRI are also discussed for metabolic bone diseases as potentially applied via PET-MRI.
RECENT FINDINGS
Etiologies and mechanisms of metabolic bone disease can be complex where molecular changes precede structural changes. Although PET-MRI has yet to be applied directly to metabolic bone disease, possible applications exist since PET, specifically F-NaF PET, can quantitatively track changes in bone metabolism and is useful for assessing treatment, while MRI can give detailed information on bone water concentration, porosity, and architecture through novel techniques such as UTE and ZTE MRI. Earlier detection and further understanding of metabolic bone disease via PET and MRI could lead to better treatment and prevention. More research using this modality is needed to further understand how it can be implemented in this realm.
目的综述
本文旨在总结正电子发射断层扫描-磁共振成像（PET-MRI）这一混合成像模式在代谢性骨病中的应用现状。同时，还探讨了 PET 和 MRI 在代谢性骨病中的应用进展，因为它们可能通过 PET-MRI 得到应用。
最近的发现
代谢性骨病的病因和发病机制可能较为复杂，其中分子变化先于结构变化。虽然 PET-MRI 尚未直接应用于代谢性骨病，但由于正电子发射断层扫描（PET），特别是 F-NaF PET，可定量追踪骨代谢变化，对评估治疗具有重要作用，而磁共振成像（MRI）可通过新技术如 UTE 和 ZTE MRI 提供骨水浓度、孔隙率和结构的详细信息，因此可能存在应用。通过 PET 和 MRI 更早地发现和进一步了解代谢性骨病，可能会导致更好的治疗和预防。需要更多的研究来进一步了解如何在这一领域实施该模式。
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