Polyamine metabolism as related to growth and hormones.

Previous work had revealed a connection between high histamine formation and certain types of rapid growth. Since then evidences have accumulated that diamines abd polyamines affect an impressive number of reactions pertinent to cell growth and proliferation. In studies on polyamine metabolism as related to growth and hormones we have preferentially been working with three types of biological model systems, i.e. the pregnant rat, the gonadotrophin stimulated rat ovary and the mouse kidney induced to growth by androgenic or anabolic steroids.