鸡主动脉组织中前列环素生物合成的缺乏。

Lack of prostacyclin biosynthesis by aortic tissue of the chicken.

作者信息

Claeys M, Wechsung E, Herman A G, Nugteren D H

出版信息

Prostaglandins. 1981 May;21(5):739-49. doi: 10.1016/0090-6980(81)90231-8.

Abstract

The capacity of chicken aorta to produce prostaglandins both from exogenous and endogenous arachidonic acid has been evaluated. The metabolism of arachidonic acid in this tissue is mainly directed to PGE2 and, in contrast to mammalian species, virtually no prostacyclin synthetase is present. However, the capacity of chicken thrombocytes to generate thromboxane A2 and 12-L-hydroxy-5, 8, 10, 14-eicosatetraenoic acid is similar to that observed for the mammalian blood platelets.

摘要

已经评估了鸡主动脉从外源性和内源性花生四烯酸产生前列腺素的能力。该组织中花生四烯酸的代谢主要导向前列腺素E2，并且与哺乳动物不同，几乎不存在前列环素合成酶。然而，鸡血小板产生血栓素A2和12-L-羟基-5,8,10,14-二十碳四烯酸的能力与在哺乳动物血小板中观察到的相似。